How Does 6-OXO Work?
4-Androstene-3,6,17-trione, commonly known as 6-OXO, has been the subject of studies since the 80s.
Back then, the focus was on its ability to bind to the aromatase enzyme and disable it from converting testosterone into estrogenic compounds, which had very important implications for men suffering from estrogen dominance.
Why is this important?
Testosterone vs. Aromatase
If you’re a man with low testosterone levels, you’re going to be experiencing a lot of negative symptoms including weight gain, muscle loss, depression, and man-boobs.
Low testosterone is a vicious cycle and one that’s hard to break out of.
Once your body increases the production of estrogen, your current levels of testosterone are more likely to continue to be converted into estrogen, pushing your t-levels further and further down. 6-OXO was thought to be an effective way to pull the plug on this conversion while promoting natural testosterone production.
Theoretically, the result would be testosterone levels that return to normal and aromatase that is permanently blocked from causing its mayhem. Sounds great, right?
What does science have to say about 6-OXO?
What Does Science Say about 6-OXO?
1. Increased Testosterone
A small-scale study involving 16 men had subjects supplementing with either 300 mg or 600 mg of 6-OXO for eight weeks.
During 5 blood samples, levels of the following were checked: total testosterone, free testosterone, dihydrotestosterone, estradiol, estriol, estrone, SHBG, luteinizing hormone, follicle stimulating hormone, growth hormone, cortisol, and FT/estradiol.
For many of these key variables, there wasn’t a big difference between the two groups; however, when it came to testosterone and DHT, this is where there was a dramatic difference.
Free testosterone levels had increased 90% for the 300 mg 6-OXO group and 84% for the 600 mg 6-OXO group.
As for DHT, which is a far more androgenic hormone than testosterone, levels increased 192% with 300 mg and 265% with 600 mg. (1)
Side Effects of 6-OXO
The number one side effect of 6-OXO has to do with estrogen suppression. Seems like a good thing, right?
Just because you’re a man doesn’t mean your body runs on only testosterone.
Estrogen, believe it or not, is just as important for your health as testosterone.
Since 6-OXO is an aromatase inhibitor, which blocks the conversion of testosterone into estrogen. If levels of estrogen get too low, the side effects will mimic that of low testosterone!
Symptoms of low estrogen include:
- Mood swings
- Low libido
- Muscle loss
- Fat gain
With that said, I must stress again that if you’re going to try 6-OXO, then you should get your testosterone and estrogen levels checked throughout the cycle.
Other common side effects from the increase of DHT while using 6-OXO include
- Hair loss – You can remedy this by taking saw palmetto
- Prostate issues – Again, saw palmetto will be helpful here
Highlighted Benefits of 6-OXO
Shown to promote the following:
- Dramatic increase in testosterone
- Boosts dihydrotestosterone (DHT)
May help to trigger the following benefits:
- Protection from catabolism
- Lean muscle mass growth
- Increase in strength levels
- Support for fat burning
6-OXO is a proven testosterone booster and estrogen blocker.
If you have confirmed low testosterone levels, then 6-OXO may be a great alternative to expensive medical treatments.
Be warned though, if you have healthy t-levels, taking 6-OXO may cause estrogen suppression, which produces the same side effects as low testosterone.
Have you used 6-OXO (4-AT)?
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- Rohle D, Wilborn C, Taylor L, Mulligan C, Kreider R, Willoughby D.
Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males.
Journal of the International Society of Sports Nutrition. 2007;4:13. doi:10.1186/1550-2783-4-13.
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